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GW Pharmaceuticals Commences Phase 1 Clinical Trial of GWP42006 as a Potential Treatment for Epilepsy

on . Posted in Medical Cannabis News & Information

London, UK; 18 September 2013: GW Pharmaceuticals plc (Nasdaq: GWPH, AIM: GWP, "GW") announced today it has commenced a Phase 1 clinical trial of product candidate GWP42006 for the treatment of epilepsy.

Over the last five years, GW has conducted an extensive pre-clinical cannabinoid research program in the field of epilepsy in collaboration with the University of Reading in the United Kingdom. This research has led to the emergence of a number of promising cannabinoid therapeutic candidates showing anti-epileptic effects. GWP42006, one of the most promising of those candidates, is a non-psychoactive cannabinoid extracted from specific chemotypes of the cannabis plant which has shown the ability to treat seizures in pre-clinical models of epilepsy with significantly fewer side effects than currently approved anti-epileptic drugs1.

New Study Finds Cannabis May Have Neuroprotective Effects

on . Posted in Medical Cannabis News & Information

A new study, published in the August edition of Neuropharmacology, has found that cannabis may serve as a neuroprotectant.

Researchers from the University Hospital Puerta de Hierro Majadahonda, in Madrid, Spain, examined the effect of CBD when applied to a hypoxic-ischemic (HI) brain injury model (most common in instances such as cardiac arrest, when blood flow stops or slows, and oxygen can’t effectively reach the brain). The scientists interrupted carotid blood flow and reduced oxygen intake levels to 10% in animal subjects for 30 minutes. The damage of the HI injury was immense:

New Study: Cannabis May Treat Brain Damage Caused by Heavy Alcohol Consumption

on . Posted in Medical Cannabis News & Information

A new study published last week by the journal Pharmacology Biochemistry and Behavior has found that cannabis may reduce the brain damage associated with long-term, heavy alcohol consumption.

According to researchers, “the current study aimed to advance the preclinical development of transdermal delivery of cannabidiol (CBD) for the treatment of alcohol-induced neurodegeneration.”

For the study, rat models were treated with two forms of administered cannabidiol (a compound of cannabis), through a transdermal gel, and an intraperitoneal injection.

Cannabis Kills Brain Cancer Cells, According to Study

on . Posted in Medical Cannabis News & Information

A study published in the Journal of Clinical Investigation found that THC (delta-9-tetrahydrocannabinol) – a prime component of cannabis can kill brain cancer cells by causing them to self-digest.

Researchers for the study examined mice subjects which were implanted with human cancer cells, as well as several human subjects with brain tumors, and found that THC causes brain cancer cells to undergo a process called autophagy; according to WebMD, autophagy is the “breakdown of a cell that occurs when the cell essentially self-digests.”

New Study: Exercise Increases THC Concentrations in Regular Cannabis Consumers

on . Posted in Medical Cannabis News & Information

According to a new study published in the journal Drug and Alcohol Dependence, exercise can increase the concentration of THC in the blood of cannabis consumers.

For the study, “cannabis users completed 35 min of exercise on a stationary bicycle in either a fed or overnight fasted state.” Following this, “Plasma cannabinoid levels were assessed prior to exercise, immediately post-exercise and 2 h post-exercise. Plasma samples were also analyzed for indices of lipolysis (free fatty acids (FFA) and glycerol).”