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GW Pharmaceuticals Commences Phase 1 Clinical Trial of GWP42006 as a Potential Treatment for Epilepsy

London, UK; 18 September 2013: GW Pharmaceuticals plc (Nasdaq: GWPH, AIM: GWP, "GW") announced today it has commenced a Phase 1 clinical trial of product candidate GWP42006 for the treatment of epilepsy.

Over the last five years, GW has conducted an extensive pre-clinical cannabinoid research program in the field of epilepsy in collaboration with the University of Reading in the United Kingdom. This research has led to the emergence of a number of promising cannabinoid therapeutic candidates showing anti-epileptic effects. GWP42006, one of the most promising of those candidates, is a non-psychoactive cannabinoid extracted from specific chemotypes of the cannabis plant which has shown the ability to treat seizures in pre-clinical models of epilepsy with significantly fewer side effects than currently approved anti-epileptic drugs1.

New Study Finds Cannabis May Have Neuroprotective Effects

A new study, published in the August edition of Neuropharmacology, has found that cannabis may serve as a neuroprotectant.

Researchers from the University Hospital Puerta de Hierro Majadahonda, in Madrid, Spain, examined the effect of CBD when applied to a hypoxic-ischemic (HI) brain injury model (most common in instances such as cardiac arrest, when blood flow stops or slows, and oxygen can’t effectively reach the brain). The scientists interrupted carotid blood flow and reduced oxygen intake levels to 10% in animal subjects for 30 minutes. The damage of the HI injury was immense:

New Study: Cannabis May Treat Brain Damage Caused by Heavy Alcohol Consumption

A new study published last week by the journal Pharmacology Biochemistry and Behavior has found that cannabis may reduce the brain damage associated with long-term, heavy alcohol consumption.

According to researchers, “the current study aimed to advance the preclinical development of transdermal delivery of cannabidiol (CBD) for the treatment of alcohol-induced neurodegeneration.”

For the study, rat models were treated with two forms of administered cannabidiol (a compound of cannabis), through a transdermal gel, and an intraperitoneal injection.

Cannabis Kills Brain Cancer Cells, According to Study

A study published in the Journal of Clinical Investigation found that THC (delta-9-tetrahydrocannabinol) – a prime component of cannabis can kill brain cancer cells by causing them to self-digest.

Researchers for the study examined mice subjects which were implanted with human cancer cells, as well as several human subjects with brain tumors, and found that THC causes brain cancer cells to undergo a process called autophagy; according to WebMD, autophagy is the “breakdown of a cell that occurs when the cell essentially self-digests.”

New Study: Exercise Increases THC Concentrations in Regular Cannabis Consumers

According to a new study published in the journal Drug and Alcohol Dependence, exercise can increase the concentration of THC in the blood of cannabis consumers.

For the study, “cannabis users completed 35 min of exercise on a stationary bicycle in either a fed or overnight fasted state.” Following this, “Plasma cannabinoid levels were assessed prior to exercise, immediately post-exercise and 2 h post-exercise. Plasma samples were also analyzed for indices of lipolysis (free fatty acids (FFA) and glycerol).”

Cannabis Could be Key to Treating Anorexia, According to Study

A new study published by the European Journal of Nuclear Medicine and Molecular Imaging has found that anorexia causes a “widespread transient disturbance” in the body’s endocannabinoid system, indicating that cannabis consumption could solve much of the problem by fixing this disturbance.

According to the study’s abstract; “Using [18F]MK-9470 and small animal positron emission tomography (PET), we investigated for the first time cerebral changes in type 1 cannabinoid (CB1) receptor binding in vivo in the activity-based rat model of anorexia (ABA), in comparison to distinct motor- and food-related control conditions and in relation to gender and behavioural variables.”

Mum refuses chemo and gives cannabis to three-year-old son to treat cancer

A desperate mother has defied conventional medical advice by treating her dying son with cannabis.

Little Landon Riddle is three years old and was given just days to live after being diagnosed with leukaemia when he was two.

He had several bouts of gruelling chemo and radiotherapy which, although they shrank the tumour, made him very sick.

New Study: Cannabis May Help Heal the Brain After Injury

A new study published in the journal Cerebral Cortex has found evidence that activation of the body’s cannabinoid receptors may lead to neuroprotective benefits which can help heal the brain after a traumatic injury.

According to researchers for the study; “The results provided the first evidence for the involvement of ECS [endocannabinoid system] in the neuroprotective action of minocycline on brain edema, neurological impairment, diffuse axonal injury, and microglial activation, since all these effects were prevented by the CB1 and CB2 receptor antagonists.”

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