The number of drug-related deaths in Ireland increased by 65% in the eight years to 2005, according to figures published today by the Health Research Board.
The board says 242 deaths were recorded in 1998, rising to 400 in 2005.
The majority of fatalities were men aged between 20 and 40.
Heroin was involved in 20% of the deaths, while the number of deaths which involved cocaine increased from five in 1998 to 34 in 2005.
Alcohol was also found to be a factor in one-quarter of all drug-related deaths over the eight-year period.
Elsewhere, the HRB figures show that 33 teenagers died from solvent abuse in the years between 1998 and 2005.